This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Silicon dioxide is an ingredient found in a variety of supplements and vitamins.

Brand Names
Gelusil, Pediacare Gas Relief
Generic Name
Silicon dioxide
DrugBank Accession Number
DB11132
Background

Silicon dioxide, or silica, is an oxide of silicon with the chemical formula SiO2. It is found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite as transparent and tasteless crystals. Inhalation of fine crystals is toxic to humans leading to respiratory toxicity. In powdered food products and pharmaceutical tablets, silicon dioxide is added as a flow agent to absorb water. Colloidal silica is also used as a wine, beer, and juice fining agent or stabilizer.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 60.0843
Monoisotopic: 59.966755777
Chemical Formula
O2Si
Synonyms
  • Colloidal silica
  • Colloidal silicon dioxide
  • Diatomaceous earth
  • Diatomaceous silica
  • Diatomite
  • Infusorial earth
  • Kieselsäureanhydrid
  • Silica
  • Silica gel
  • Silica, colloidal
  • Siliceous earth
  • Siliceous earth, purified
  • Silicon dioxide (amorphous)
  • Silicon dioxide, colloidal
  • Silicon dioxide, fumed
  • Silicon oxide
  • Siliziumdioxid
External IDs
  • E-551
  • INS NO.551
  • INS-551
  • U 333

Pharmacology

Indication

Not Available

Pharmacology
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Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UMacrophage receptor MARCONot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
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dosage, form, labeller, route of administration, and marketing period.
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
2080 Dentistry Night FreshPaste, dentifrice15 g/100gDentalAekyung Industrial Co., Ltd.2017-02-03Not applicableUS flag
2080 Dentistry Night RepairPaste, dentifrice15 g/100gDentalAekyung Industrial Co., Ltd.2017-02-03Not applicableUS flag
28tak Doux ToothPaste, dentifrice4.8 g/60gOralElmeditec Co.,Ltd2018-07-01Not applicableUS flag
Antiseptic DisinfectantLiquid0.56 g/100mLTopicalNano Care Deutschland AG2020-03-28Not applicableUS flag
Chlorine Dioxide Air Sterilization CardPowder30 g/100gTopicalHeyuan City Wingart Enterprises Co., Ltd.2020-03-30Not applicableUS flag
Dr. Zenni GGOGGOMA ToothpasteRaspberry flavorPaste, dentifrice6 g/100gDentalZeniton Co.,Ltd.2019-02-01Not applicableUS flag
Dr. Zenni GGOGGOMA ToothpasteVanilla flavorPaste, dentifrice6 g/100gDentalZeniton Co.,Ltd.2019-02-01Not applicableUS flag
Dr. Zenni Kids tooth (Baby)Paste, dentifrice6 g/100gDentalZeniton Co.,Ltd.2019-02-01Not applicableUS flag
Dr.EL DOUX TOOTHPaste, dentifrice8 g/100gDentalDr. EL CO., LTD.2019-08-01Not applicableUS flag
Evertox Special Bath PreparationsPowder20 g/100gTopicalKmtr Co., Ltd.2015-01-11Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
28tak Clair ToothSilicon dioxide (4.8 g/60g) + Sodium fluorophosphate (0.13 g/60g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUS flag
Alegria NeoSilicon dioxide (2.80 g/20g) + Allantoin (0.008 g/20g)Paste, dentifriceTopicalSeowangmo Corporation2017-10-01Not applicableUS flag
BAMBOO SALT Eunganggo Jook YeomSilicon dioxide (20 g/100g) + Aminocaproic acid (0.05 g/100g) + Curcuma xanthorrhiza oil (0.025 g/100g) + Glycyrrhizinate dipotassium (0.04 g/100g) + Sea salt (3 g/100g) + Sodium fluoride (0.22 g/100g) + Ursodeoxycholic acid (0.02 g/100g)PasteDentalLg Household & Health Care Ltd.2011-03-15Not applicableUS flag
BAMBOO SALT Eunganggo Jook Yeom ToothpasteSilicon dioxide (20 g/100g) + Aminocaproic acid (0.05 g/100g) + Curcuma xanthorrhiza oil (0.025 g/100g) + Glycyrrhizinate dipotassium (0.04 g/100g) + Sea salt (3 g/100g) + Sodium fluoride (0.22 g/100g) + Ursodeoxycholic acid (0.02 g/100g)PasteDentalLg Household & Health Care Ltd.2010-05-25Not applicableUS flag
Calcium and Magnesium 1:1 Plus TabletsSilicon dioxide (5 mg) + Calcium (250 mg) + Cholecalciferol (100 unit) + Magnesium (250 mg) + Manganese (1 mg) + Potassium (20 mg) + Zinc (5 mg)TabletOralAlbi Naturals1998-02-202009-07-15Canada flag
Cheee Gold Plus ToothSilicon dioxide (7.8 g/130g) + alpha-Tocopherol acetate (0.13 g/130g)Paste, dentifriceOralNature Plus2020-07-01Not applicableUS flag
Chunzam Silk Amino Acid ToothSilicon dioxide (4 g/100g) + Sodium fluorophosphate (0.33 g/100g) + alpha-Tocopherol acetate (0.1 g/100g)Paste, dentifriceDentalChunzam Bio Co Ltd2016-11-11Not applicableUS flag
Colgate Total Advanced Health Daily RepairSilicon dioxide (5 % w/w) + Sodium fluoride (0.243 % w/w) + Triclosan (0.3 % w/w)Paste, dentifriceDentalColgate Palmolive2016-01-152019-08-01Canada flag
Colgate Total Advanced Health SensitiveSilicon dioxide (5 % w/w) + Sodium fluoride (0.243 % w/w) + Triclosan (0.3 % w/w)Paste, dentifriceDentalColgate Palmolive2012-07-232019-08-01Canada flag
Colgate Total Gum DefenseSilicon dioxide (50 mg/1g) + Sodium fluoride (2.4 mg/1g) + Triclosan (3 mg/1g)Paste, dentifriceDentalColgate-Palmolive2011-06-252013-12-10US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
28tak Clair ToothSilicon dioxide (4.8 g/60g) + Sodium fluorophosphate (0.13 g/60g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUS flag
28tak Doux ToothSilicon dioxide (4.8 g/60g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUS flag
Alegria NeoSilicon dioxide (2.80 g/20g) + Allantoin (0.008 g/20g)Paste, dentifriceTopicalSeowangmo Corporation2017-10-01Not applicableUS flag
Antiseptic DisinfectantSilicon dioxide (0.56 g/100mL)LiquidTopicalNano Care Deutschland AG2020-03-28Not applicableUS flag
Cheee Gold Plus ToothSilicon dioxide (7.8 g/130g) + alpha-Tocopherol acetate (0.13 g/130g)Paste, dentifriceOralNature Plus2020-07-01Not applicableUS flag
Chlorine Dioxide Air Sterilization CardSilicon dioxide (30 g/100g)PowderTopicalHeyuan City Wingart Enterprises Co., Ltd.2020-03-30Not applicableUS flag
Chunzam Silk Amino Acid ToothSilicon dioxide (4 g/100g) + Sodium fluorophosphate (0.33 g/100g) + alpha-Tocopherol acetate (0.1 g/100g)Paste, dentifriceDentalChunzam Bio Co Ltd2016-11-11Not applicableUS flag
DIO Enamel Coating Pen Pro ToothSilicon dioxide (6 g/100g) + Calcium phosphate, tribasic (20 g/100g) + alpha-Tocopherol acetate (0.2 g/100g)Paste, dentifriceDentalDio2016-05-01Not applicableUS flag
Dio WhiteningSilicon dioxide (7 g/100g) + Hydrogen peroxide (2.14 g/100g) + alpha-Tocopherol acetate (0.2 g/100g)Paste, dentifriceDentalDio2015-01-22Not applicableUS flag
Divinetree Ssak Shark Kids ToothSilicon dioxide (6.50 g/50g) + Alcloxa (0.08 g/50g)Paste, dentifriceOralK.biocos2019-11-01Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
ETJ7Z6XBU4
CAS number
7631-86-9
InChI Key
VYPSYNLAJGMNEJ-UHFFFAOYSA-N
InChI
InChI=1S/O2Si/c1-3-2
IUPAC Name
silanedione
SMILES
O=[Si]=O

References

General References
Not Available
Human Metabolome Database
HMDB0035659
PubChem Compound
22644374
PubChem Substance
347827911
ChemSpider
22683
RxNav
314826
ChEBI
30563
ChEMBL
CHEMBL3188292
Wikipedia
Silicon_dioxide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentDental Decay1
4CompletedTreatmentGastro-esophageal Reflux Disease (GERD)1
3CompletedOtherCaries1
3CompletedTreatmentEnamel Erosion1
3CompletedTreatmentHypersensitivity Dentin1
3CompletedTreatmentPlaque, Dental1
2CompletedNot AvailableAcid Reflux Disease / Gastro-esophageal Reflux Disease (GERD) / Heartburn / Regurgitation1
2CompletedTreatmentAcute Diarrhea1
2CompletedTreatmentCardiac Involvement / Light Chain (AL) Amyloidosis1
2CompletedTreatmentDepression1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Paste, dentifriceDental15 g/100g
Paste, dentifriceOral
Paste, dentifriceOral4.8 g/60g
Paste, dentifriceTopical
LiquidTopical0.56 g/100mL
PasteDental
PowderTopical30 g/100g
Paste, dentifriceDental
Paste, dentifriceDental6 g/100g
Paste, dentifriceDental8 g/100g
Granule, effervescentOral
PowderTopical20 g/100g
PasteDental8 g/100g
Paste, dentifriceDental17 g/100g
PowderTopical
Tablet, chewableOral
CapsuleOral
Paste, dentifriceTopical15.0 g/100g
PasteOral
PasteOral170 mg/1g
GelDental1.71 g/60g
GelDental1.425 g/50g
KitDental
LiquidOral
EmulsionOral
Paste, dentifriceOral24.0 g/160g
LiquidTopical
Capsule
LiquidOral80 mg / 5 mL
GelOral80 mg / 5 mL
CapsuleOral
CapsuleOral5 mg / cap
Solution / dropsOral
SolutionOral2 g/100mL
StickTopical0.88 g/11g
PowderTopical51 kg/100kg
Paste, dentifriceDental2.14 g/100g
PasteTopical
Capsule, gelatin coatedOral
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.66ChemAxon
pKa (Strongest Basic)-8.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area34.14 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity2.89 m3·mol-1ChemAxon
Polarizability3.28 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Drugtargets2
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Specific Function
Scavenger receptor activity
Gene Name
MARCO
Uniprot ID
Q9UEW3
Uniprot Name
Macrophage receptor MARCO
Molecular Weight
52657.905 Da
References
  1. Thakur SA, Hamilton R Jr, Pikkarainen T, Holian A: Differential binding of inorganic particles to MARCO. Toxicol Sci. 2009 Jan;107(1):238-46. doi: 10.1093/toxsci/kfn210. Epub 2008 Oct 4. [Article]

Drug created at December 03, 2015 16:51 / Updated at December 08, 2021 01:57