Eukaryotic translation initiation factor 3 subunit F

BE0009017ProteinHumansEIF3F

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). It is acted on by 1 drug in DrugBank.

Gene name
EIF3F
UniProtKB entry
O00303Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
357 residues · 37,563 Da
Also known as
Deubiquitinating enzyme eIF3f · eIF-3-epsilon · eIF3 p47 · eIF3f · EIF3S5

Resolves to

Protein
UniProtO00303UniProt nameEIF3F_HUMAN
Gene
HGNCHGNC:3275NCBI Gene8665GeneCardsEIF3F
Pharmacology
KEGGhsa:8665
Structure
PDB3J8BPDB3J8CPDB6YBD
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Eukaryotic translation initiation factor 3 subunit F, and which indications are they being tested in?

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