RuvB-like 2

BE0009019ProteinHumansRUVBL2

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868,... It is acted on by 1 drug in DrugBank.

Gene name
RUVBL2
UniProtKB entry
Q9Y230Swiss-Prot
Cellular location
Nucleus matrix
Residues / weight
463 residues · 51,156 Da
Also known as
3.6.4.12 · 48 kDa TATA box-binding protein-interacting protein · 48 kDa TBP-interacting protein · 51 kDa erythrocyte cytosolic protein · ECP-51

Resolves to

Protein
UniProtQ9Y230UniProt nameRUVB2_HUMAN
Gene
HGNCHGNC:10475NCBI Gene10856GeneCardsRUVBL2
Pharmacology
KEGGhsa:10856
Structure
PDB2CQAPDB2XSZPDB3UK6
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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32GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which compounds in development act on RuvB-like 2, and which indications are they being tested in?

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