Splicing factor 3B subunit 3

BE0009020ProteinHumansSF3B3

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10490618, PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). It is acted on by 2 drugs in DrugBank.

Gene name
SF3B3
UniProtKB entry
Q15393Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,217 residues · 135,576 Da
Also known as
KIAA0017 · Pre-mRNA-splicing factor SF3b 130 kDa subunit · SAP 130 · SAP130 · SF3b130

Resolves to

Protein
UniProtQ15393UniProt nameSF3B3_HUMAN
Gene
HGNCHGNC:10770NCBI Gene23450GeneCardsSF3B3
Pharmacology
KEGGhsa:23450
Structure
PDB5IFEPDB5O9ZPDB5Z56
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
18GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Splicing factor 3B subunit 3, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In