DNA sliding clamp PCNA

BE0009045ProteinHumansPCNA

Confers DNA tethering and processivity to DNA polymerases and other proteins (PubMed:24695737, PubMed:24939902, PubMed:35585232). It is acted on by 4 drugs in DrugBank.

Gene name
PCNA
UniProtKB entry
P12004Swiss-Prot
Cellular location
Nucleus
Residues / weight
261 residues · 28,768 Da
Also known as
Cyclin · PCNA · Proliferating cell nuclear antigen

Resolves to

Protein
UniProtP12004UniProt namePCNA_HUMAN
Gene
HGNCHGNC:8729NCBI Gene5111GeneCardsPCNA
Pharmacology
KEGGhsa:5111
Structure
PDB1AXCPDB1U76PDB1U7B
Drugs

What you can answer from here — as of June 05, 2026

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
7Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
66+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on DNA sliding clamp PCNA, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In