Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3.
- Mechanism
- Curator reviewed · 1 reference
Liothyronine replaces endogenous thyroid hormone and then exerts its physiologic effects by controlling DNA transcription and protein synthesis. This effect on DNA is obtained by the binding of liothyronine to the thyroid receptors attached to DNA. Exogenous liothyronine exerts all the normal effects of the endogenous thyroid T3 hormone. Hence, it increases energy expenditure, accelerates the rate of cellular oxidation stimulating growth, maturation, and metabolism of the body tissues, aids in myelination of nerves and development of synaptic processes in the nervous system and enhances carbohydrate and protein metabolism.
- Primary indication
- Liothyronine is officially approved for the following indications: Replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism.Curator reviewed · 9 structured indications
- Formula / weight
- C15H12I3NO4 · 650.9735 g/mol (avg)
- First approval
- Canada, 2011 · United States, 1956
- Also known as
- L-T3 · LT3 · Triiodothyronine
- Code names
- NSC-80203
- Brand names
Resolves to
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Which drugs share a target with Liothyronine, and which of those have an active Phase 3 trial?
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