C4b-binding protein alpha chain

Details

Name
C4b-binding protein alpha chain
Kind
protein
Synonyms
  • C4BP
  • Proline-rich protein
  • PRP
Gene Name
C4BPA
UniProtKB Entry
P04003Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0049812|C4b-binding protein alpha chain
MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAA
PMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELR
NGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPD
IRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCR
KPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCI
NLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGC
EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTP
SCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQC
KALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEW
ETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLDKEL
Number of residues
597
Molecular Weight
67032.63
Theoretical pI
Not Available
GO Classification
Processes
response to symbiotic bacterium / T cell mediated immunity
General Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component
Specific Function
Rna binding
Pfam Domain Function
Signal Regions
1-48
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0049813|C4b-binding protein alpha chain (C4BPA)
ATGCACCCCCCAAAAACTCCATCTGGGGCTCTTCATAGAAAAAGGAAAATGGCAGCCTGG
CCCTTCTCCAGGCTGTGGAAAGTCTCTGATCCAATTCTCTTCCAAATGACCTTGATCGCT
GCTCTGTTGCCTGCTGTTCTTGGCAATTGTGGTCCTCCACCCACTTTATCATTTGCTGCC
CCGATGGATATTACGTTGACTGAGACACGCTTCAAAACTGGAACTACTCTGAAATACACC
TGCCTCCCTGGCTACGTCAGATCCCATTCAACTCAGACGCTTACCTGTAATTCTGATGGC
GAATGGGTGTATAACACCTTCTGTATCTACAAACGATGCAGACACCCAGGAGAGTTACGT
AATGGGCAAGTAGAGATTAAGACAGATTTATCTTTTGGATCACAAATAGAATTCAGCTGT
TCAGAAGGATTTTTCTTAATTGGCTCAACCACTAGTCGTTGTGAAGTCCAAGATAGAGGA
GTTGGCTGGAGTCATCCTCTCCCACAATGTGAAATTGTCAAGTGTAAGCCTCCTCCAGAC
ATCAGGAATGGAAGGCACAGCGGTGAAGAAAATTTCTACGCATACGGCTTTTCTGTCACC
TACAGCTGTGACCCCCGCTTCTCACTCTTGGGCCATGCCTCCATTTCTTGCACTGTGGAG
AATGAAACAATAGGTGTTTGGAGACCAAGCCCTCCTACCTGTGAAAAAATCACCTGTCGC
AAGCCAGATGTTTCACATGGGGAAATGGTCTCTGGATTTGGACCCATCTATAATTACAAA
GACACTATTGTGTTTAAGTGCCAAAAAGGTTTTGTTCTCAGAGGCAGCAGTGTAATTCAT
TGTGATGCTGATAGCAAATGGAATCCTTCTCCTCCTGCTTGTGAGCCCAATAGTTGTATT
AATTTACCAGACATTCCACATGCTTCCTGGGAAACATATCCTAGGCCGACAAAAGAGGAT
GTGTATGTTGTTGGGACTGTGTTAAGGTACCGCTGTCATCCTGGCTACAAACCCACTACA
GATGAGCCTACGACTGTGATTTGTCAGAAAAATTTGAGATGGACCCCATACCAAGGATGT
GAGGCGTTATGTTGCCCTGAACCAAAGCTAAATAATGGTGAAATCACTCAACACAGGAAA
AGTCGTCCTGCCAATCACTGTGTTTATTTCTATGGAGATGAGATTTCATTTTCATGTCAT
GAGACCAGTAGGTTTTCAGCTATATGCCAAGGAGATGGCACGTGGAGTCCCCGAACACCA
TCATGTGGAGACATTTGCAATTTTCCTCCTAAAATTGCCCATGGGCATTATAAACAATCT
AGTTCATACAGCTTTTTCAAAGAAGAGATTATATATGAATGTGATAAAGGCTACATTCTG
GTCGGACAGGCGAAACTCTCCTGCAGTTATTCACACTGGTCAGCTCCAGCCCCTCAATGT
AAAGCTCTGTGTCGGAAACCAGAATTAGTGAATGGAAGGTTGTCTGTGGATAAGGATCAG
TATGTTGAGCCTGAAAATGTCACCATCCAATGTGATTCTGGCTATGGTGTGGTTGGTCCC
CAAAGTATCACTTGCTCTGGGAACAGAACCTGGTACCCAGAGGTGCCCAAGTGTGAGTGG
GAGACCCCCGAAGGCTGTGAACAAGTGCTCACAGGCAAAAGACTCATGCAGTGTCTCCCA
AACCCAGAGGATGTGAAAATGGCCCTGGAGGTATATAAGCTGTCTCTGGAAATTGAACAA
CTGGAACTACAGAGAGACAGCGCAAGACAATCCACTTTGGATAAAGAACTATAA
Chromosome Location
1
Locus
1q32.2
External Identifiers
ResourceLink
UniProtKB IDP04003
UniProtKB Entry NameC4BPA_HUMAN
GeneCard IDC4BPA
HGNC IDHGNC:1325
PDB ID(s)2A55, 4B0F, 5HYP, 5HYT, 5HYU, 5HZP, 5I0Q
KEGG IDhsa:722
NCBI Gene ID722
General References
  1. Matsuguchi T, Okamura S, Aso T, Sata T, Niho Y: Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein. Biochem Biophys Res Commun. 1989 Nov 30;165(1):138-44. [Article]
  2. Aso T, Okamura S, Matsuguchi T, Sakamoto N, Sata T, Niho Y: Genomic organization of the alpha chain of the human C4b-binding protein gene. Biochem Biophys Res Commun. 1991 Jan 15;174(1):222-7. [Article]
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  5. Lintin SJ, Lewin AR, Reid KB: Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence. FEBS Lett. 1988 May 23;232(2):328-32. [Article]
  6. Lintin SJ, Reid KB: Studies on the structure of the human C4b-binding protein gene. FEBS Lett. 1986 Aug 11;204(1):77-81. [Article]
  7. Chung LP, Bentley DR, Reid KB: Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system. Biochem J. 1985 Aug 15;230(1):133-41. [Article]
  8. Chung LP, Gagnon J, Reid KB: Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment. Mol Immunol. 1985 Apr;22(4):427-35. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Copperapproved, investigationalunknowntargetDetails
Zincapproved, investigationalunknowntargetDetails
Zinc acetateapproved, investigationalunknowntargetDetails
Zinc chlorideapproved, investigationalunknowntargetmodulatorDetails
Zinc sulfate, unspecified formapproved, experimentalunknowntargetmodulatorDetails