Complement factor H

BE0009053ProteinHumansCFH

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. It is acted on by 5 drugs in DrugBank.

Gene name
CFH
UniProtKB entry
P08603Swiss-Prot
Cellular location
Secreted
Residues / weight
1,231 residues · 139,095 Da
Also known as
H factor 1 · HF · HF1 · HF2

Resolves to

Protein
UniProtP08603UniProt nameCFAH_HUMAN
Gene
HGNCHGNC:4883NCBI Gene3075GeneCardsCFH
Pharmacology
KEGGhsa:3075
Structure
PDB1HAQPDB1HCCPDB1HFH
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement factor H, how selective are they, and which programs against it are still in active trials?

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