Clusterin

BE0009055ProteinHumansCLU

Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). It is acted on by 7 drugs in DrugBank.

Gene name
CLU
UniProtKB entry
P10909Swiss-Prot
Cellular location
Secreted
Residues / weight
449 residues · 52,494 Da
Also known as
Aging-associated gene 4 protein · Apo-J · APOJ · Apolipoprotein J · CLI

Resolves to

Protein
UniProtP10909UniProt nameCLUS_HUMAN
Gene
HGNCHGNC:2095NCBI Gene1191GeneCardsCLU
Pharmacology
IUPHAR/GtoPdb3195KEGGhsa:1191
Structure
PDB7ZETPDB7ZEU
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
36GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
61+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Clusterin, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In