Inter-alpha-trypsin inhibitor heavy chain H2
Details
- Name
- Inter-alpha-trypsin inhibitor heavy chain H2
- Kind
- protein
- Synonyms
- IGHEP2
- Inter-alpha-inhibitor heavy chain 2
- Inter-alpha-trypsin inhibitor complex component II
- ITI heavy chain H2
- ITI-HC2
- Serum-derived hyaluronan-associated protein
- SHAP
- Gene Name
- ITIH2
- UniProtKB Entry
- P19823Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049832|Inter-alpha-trypsin inhibitor heavy chain H2 MKRLTCFFICFFLSEVSGFEIPINGLSEFVDYEDLVELAPGKFQLVAENRRYQRSLPGES EEMMEEVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFS MTVDGKTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFE LHYQEVKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGHFDGVPVI SKGQQKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFA PDNLDPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRN DLISATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVS DGDPTVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQ DTSSQLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQ IESVITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAP TAAAKRRITRSILQMSLDHHIVTPLTSLVIENEAGDERMLADAPPQDPSCCSGALYYGSK VVPDSTPSWANPSPTPVISMLAQGSQVLESTPPPHVMRVENDPHFIIYLPKSQKNICFNI DSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEISTETI TLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNVD FLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRGL QKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP
- Number of residues
- 946
- Molecular Weight
- 106462.725
- Theoretical pI
- Not Available
- GO Classification
- Functionshyaluronic acid bindingComponentscollagen-containing extracellular matrix / endoplasmic reticulum lumen
- General Function
- May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes
- Specific Function
- endopeptidase inhibitor activity
- Pfam Domain Function
- Signal Regions
- 1-18
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049833|Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) ATGAAAAGACTCACGTGCTTTTTCATCTGCTTCTTTCTTTCTGAAGTATCAGGCTTCGAA ATCCCCATAAATGGACTTTCTGAATTTGTAGACTATGAAGATCTTGTGGAACTGGCCCCA GGCAAATTTCAATTGGTGGCAGAGAACCGGAGATATCAGAGAAGCCTTCCAGGAGAATCG GAAGAAATGATGGAAGAGGTTGATCAAGTAACTCTTTATAGCTATAAAGTCCAGTCTACT ATTACTTCTCGGATGGCCACCACCATGATCCAGAGCAAAGTGGTGAACAATTCCCCGCAG CCTCAGAATGTCGTGTTTGATGTTCAGATCCCCAAAGGAGCATTCATTTCCAACTTCTCC ATGACTGTGGACGGCAAGACATTTAGGAGCTCTATTAAGGAGAAAACTGTGGGCCGAGCT CTTTATGCACAGGCCAGAGCAAAAGGCAAGACGGCTGGCTTGGTGAGGAGCAGCGCTCTT GATATGGAAAACTTCAGAACGGAAGTAAATGTCCTCCCAGGAGCAAAGGTGCAGTTCGAA CTTCACTACCAGGAGGTGAAGTGGAGGAAGCTGGGCTCCTATGAGCACAGGATCTATCTG CAACCTGGACGGCTGGCCAAACACTTAGAGGTAGATGTGTGGGTTATCGAACCACAGGGA CTGAGATTTCTTCATGTTCCCGACACATTTGAAGGCCATTTCGATGGTGTTCCGGTCATT TCTAAAGGACAACAGAAGGCGCACGTCTCCTTCAAGCCCACGGTAGCACAGCAGAGAATA TGCCCTAACTGCCGGGAGACTGCGGTAGATGGGGAACTGGTGGTGCTGTATGACGTGAAA AGAGAAGAGAAGGCTGGTGAACTGGAGGTGTTTAATGGATATTTTGTCCACTTCTTTGCT CCTGACAACCTGGACCCAATTCCCAAAAACATCCTCTTTGTCATCGATGTGAGTGGCTCC ATGTGGGGAGTTAAAATGAAACAAACTGTGGAAGCAATGAAGACCATATTGGATGACCTC AGAGCAGAAGACCATTTCTCTGTGATTGATTTCAACCAGAACATTCGAACTTGGAGAAAT GATTTAATTTCAGCTACAAAAACACAGGTTGCAGATGCCAAGAGGTATATTGAGAAAATC CAGCCCAGTGGAGGCACAAACATCAACGAAGCACTCCTACGGGCAATCTTCATTTTGAAT GAAGCCAATAACTTGGGACTGTTAGACCCCAACTCCGTCTCGCTGATCATTTTGGTTTCT GATGGAGATCCAACAGTGGGCGAACTAAAACTGTCAAAAATTCAGAAAAACGTTAAGGAG AACATCCAAGACAATATCTCCTTGTTCAGTTTGGGCATGGGATTTGATGTGGACTATGAT TTTTTGAAGAGACTGTCCAATGAAAACCATGGAATTGCACAAAGGATTTATGGAAACCAG GACACGTCTTCCCAGCTTAAGAAATTCTACAACCAGGTCTCCACTCCATTGCTCCGGAAT GTTCAGTTCAACTATCCCCATACATCAGTCACGGACGTCACTCAAAACAATTTCCATAAC TACTTTGGAGGCTCAGAGATTGTGGTGGCAGGAAAATTTGACCCTGCTAAATTGGATCAA ATAGAGAGCGTTATCACGGCGACTTCGGCTAACACGCAGTTAGTCTTGGAGACCCTGGCC CAGATGGACGACTTGCAGGATTTTCTATCGAAAGACAAGCATGCAGATCCCGATTTCACC AGGAAACTGTGGGCCTATCTAACCATCAACCAACTGCTAGCTGAACGAAGCCTGGCTCCT ACAGCTGCCGCCAAGAGAAGAATTACAAGATCGATCCTGCAGATGTCTCTAGACCACCAC ATTGTGACTCCGCTGACCTCGCTGGTGATCGAGAACGAGGCTGGGGATGAGCGCATGCTG GCGGATGCCCCACCGCAGGATCCCTCCTGCTGCTCAGGGGCCCTGTATTACGGCAGCAAA GTGGTTCCAGATTCCACCCCGTCTTGGGCCAATCCTTCACCAACGCCCGTGATCTCCATG CTGGCACAAGGATCTCAGGTGCTAGAGTCCACGCCACCCCCACATGTGATGAGAGTTGAA AATGACCCACATTTCATCATTTATCTACCAAAAAGCCAAAAGAACATTTGTTTCAATATT GACTCAGAACCTGGAAAAATCCTCAACCTGGTTTCTGACCCAGAATCAGGAATTGTAGTC AACGGTCAGCTTGTTGGTGCCAAGAAGCCCAACAATGGAAAACTAAGCACCTATTTTGGA AAACTGGGATTTTATTTCCAAAGTGAAGACATAAAAATAGAAATCAGCACTGAGACCATC ACCCTGAGCCATGGTTCTAGCACATTCTCCTTGTCCTGGTCCGACACGGCTCAAGTCACG AATCAGAGGGTGCAGATCTCAGTGAAGAAAGAAAAAGTGGTAACTATCACCCTGGATAAA GAGATGTCCTTTTCTGTTTTACTTCATCGTGTTTGGAAGAAGCATCCCGTCAATGTTGAC TTTCTGGGAATCTACATACCCCCTACAAACAAGTTCTCACCTAAAGCCCACGGACTAATA GGCCAGTTCATGCAGGAACCAAAGATACACATCTTCAATGAGAGACCAGGAAAGGACCCT GAGAAGCCAGAGGCCAGCATGGAAGTGAAGGGGCAGAAGCTGATCATCACCAGGGGCTTA CAGAAAGACTACAGAACGGATCTAGTGTTTGGAACGGACGTTACCTGCTGGTTTGTGCAC AACAGTGGAAAAGGATTCATTGACGGGCATTACAAGGATTACTTCGTGCCTCAGCTCTAC AGCTTTCTCAAACGGCCTTAA
- Chromosome Location
- 10
- Locus
- 10p14
- External Identifiers
Resource Link UniProtKB ID P19823 UniProtKB Entry Name ITIH2_HUMAN GeneCard ID ITIH2 HGNC ID HGNC:6167 KEGG ID hsa:3698 NCBI Gene ID 3698 - General References
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- Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J: TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. Biochemistry. 1994 Jun 14;33(23):7423-9. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Copper approved, investigational unknown target Details Zinc approved, investigational unknown target Details Zinc acetate approved, investigational unknown target Details Zinc chloride approved, investigational unknown target binder Details Zinc sulfate, unspecified form approved, experimental unknown target binder Details