Lys-63-specific deubiquitinase BRCC36

BE0009071ProteinHumansBRCC3

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). It is acted on by 4 drugs in DrugBank.

Gene name
BRCC3
UniProtKB entry
P46736Swiss-Prot
Cellular location
Nucleus
Residues / weight
316 residues · 36,072 Da
Also known as
3.4.19.- · BRCA1-A complex subunit BRCC36 · BRCA1/BRCA2-containing complex subunit 3 · BRCA1/BRCA2-containing complex subunit 36 · BRCC36

Resolves to

Protein
UniProtP46736UniProt nameBRCC3_HUMAN
Gene
HGNCHGNC:24185NCBI Gene79184GeneCardsBRCC3
Pharmacology
KEGGhsa:79184
Structure
PDB6H3CPDB6R8FPDB8PVY
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lys-63-specific deubiquitinase BRCC36, how selective are they, and which programs against it are still in active trials?

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