Inter-alpha-trypsin inhibitor heavy chain H4

BE0009082ProteinHumansITIH4

Type II acute-phase protein (APP) involved in inflammatory responses to trauma. It is acted on by 4 drugs in DrugBank.

Gene name
ITIH4
UniProtKB entry
Q14624Swiss-Prot
Cellular location
Secreted
Residues / weight
930 residues · 103,357 Da
Also known as
Gp120 · IHRP · Inter-alpha-inhibitor heavy chain 4 · Inter-alpha-trypsin inhibitor family heavy chain-related protein · ITI heavy chain H4

Resolves to

Protein
UniProtQ14624UniProt nameITIH4_HUMAN
Gene
HGNCHGNC:6169NCBI Gene3700GeneCardsITIH4
Pharmacology
KEGGhsa:3700
Structure
PDB9C4FPDB9C4N
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inter-alpha-trypsin inhibitor heavy chain H4, how selective are they, and which programs against it are still in active trials?

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