Immunoglobulin J chain

BE0009083ProteinHumansJCHAIN

Serves to link two monomer units of either IgM or IgA. It is acted on by 4 drugs in DrugBank.

Gene name
JCHAIN
UniProtKB entry
P01591Swiss-Prot
Cellular location
Secreted
Residues / weight
159 residues · 18,098 Da
Also known as
IGCJ · IGJ · Joining chain of multimeric IgA and IgM

Resolves to

Protein
UniProtP01591UniProt nameIGJ_HUMAN
Gene
HGNCHGNC:5713NCBI Gene3512GeneCardsJCHAIN
Pharmacology
KEGGhsa:3512
Structure
PDB6KXSPDB6LX3PDB6LXW
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Immunoglobulin J chain, how selective are they, and which programs against it are still in active trials?

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