C-type lectin domain family 4 member E

BE0009096ProteinHumansCLEC4E

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766). It is acted on by 1 drug in DrugBank.

Gene name
CLEC4E
UniProtKB entry
Q9ULY5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
219 residues · 25,072 Da
Also known as
C-type lectin superfamily member 9 · CLECSF9 · Macrophage-inducible C-type lectin · MINCLE

Resolves to

Protein
UniProtQ9ULY5UniProt nameCLC4E_HUMAN
Gene
HGNCHGNC:14555NCBI Gene26253GeneCardsCLEC4E
Pharmacology
IUPHAR/GtoPdb2929KEGGhsa:26253
Structure
PDB3WH2PDB3WH3
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C-type lectin domain family 4 member E, how selective are they, and which programs against it are still in active trials?

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