ATP synthase peripheral stalk subunit OSCP, mitochondrial

BE0009097ProteinHumansATP5PO

Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron... It is acted on by 1 drug in DrugBank.

Gene name
ATP5PO
UniProtKB entry
P48047Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
213 residues · 23,277 Da
Also known as
ATP synthase subunit O · ATP5O · ATPO · Oligomycin sensitivity conferral protein · OSCP

Resolves to

Protein
UniProtP48047UniProt nameATPO_HUMAN
Gene
HGNCHGNC:850NCBI Gene539GeneCardsATP5PO
Pharmacology
KEGGhsa:539
Structure
PDB8H9EPDB8H9IPDB8H9L
Drugs

What you can answer from here — as of June 26, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP synthase peripheral stalk subunit OSCP, mitochondrial, how selective are they, and which programs against it are still in active trials?

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