Filamin-A

BE0009099ProteinHumansFLNA

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It is acted on by 2 drugs in DrugBank.

Gene name
FLNA
UniProtKB entry
P21333Swiss-Prot
Cellular location
Cytoplasm, cell cortex
Residues / weight
2,647 residues · 280,738 Da
Also known as
ABP-280 · Actin-binding protein 280 · Alpha-filamin · Endothelial actin-binding protein · Filamin-1

Resolves to

Protein
UniProtP21333UniProt nameFLNA_HUMAN
Gene
HGNCHGNC:3754NCBI Gene2316GeneCardsFLNA
Pharmacology
KEGGhsa:2316
Structure
PDB2AAVPDB2BP3PDB2BRQ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
54GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
78+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Filamin-A, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In