Heterogeneous nuclear ribonucleoprotein D0

BE0009100ProteinHumansHNRNPD

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. It is acted on by 1 drug in DrugBank.

Gene name
HNRNPD
UniProtKB entry
Q14103Swiss-Prot
Cellular location
Nucleus
Residues / weight
355 residues · 38,434 Da
Also known as
AU-rich element RNA-binding protein 1 · AUF1 · hnRNP D0 · HNRPD

Resolves to

Protein
UniProtQ14103UniProt nameHNRPD_HUMAN
Gene
HGNCHGNC:5036NCBI Gene3184GeneCardsHNRNPD
Pharmacology
KEGGhsa:3184
Structure
PDB1HD0PDB1HD1PDB1IQT
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Heterogeneous nuclear ribonucleoprotein D0, how selective are they, and which programs against it are still in active trials?

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