Splicing factor 1

BE0009118ProteinHumansSF1

Necessary for the ATP-dependent first step of spliceosome assembly. It is acted on by 1 drug in DrugBank.

Gene name
SF1
UniProtKB entry
Q15637Swiss-Prot
Cellular location
Nucleus
Residues / weight
639 residues · 68,330 Da
Also known as
BBP · Mammalian branch point-binding protein · mBBP · Transcription factor ZFM1 · ZFM1

Resolves to

Protein
UniProtQ15637UniProt nameSF01_HUMAN
Gene
HGNCHGNC:12950NCBI Gene7536GeneCardsSF1
Pharmacology
KEGGhsa:7536
Structure
PDB1K1GPDB1O0PPDB1OPI
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Splicing factor 1, how selective are they, and which programs against it are still in active trials?

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