Probable ATP-dependent RNA helicase DDX5

BE0009162ProteinHumansDDX5

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. It is acted on by 2 drugs in DrugBank.

Gene name
DDX5
UniProtKB entry
P17844Swiss-Prot
Cellular location
Nucleus
Residues / weight
614 residues · 69,148 Da
Also known as
3.6.4.13 · DEAD box protein 5 · G17P1 · HELR · HLR1

Resolves to

Protein
UniProtP17844UniProt nameDDX5_HUMAN
Gene
HGNCHGNC:2746NCBI Gene1655GeneCardsDDX5
Pharmacology
KEGGhsa:1655
Structure
PDB3FE2PDB4A4D
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Probable ATP-dependent RNA helicase DDX5, how selective are they, and which programs against it are still in active trials?

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