Fructose-bisphosphate aldolase

BE0009172ProteinPlasmodium falciparumFBPA

Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:2190085). It is acted on by 1 drug in DrugBank.

Gene name
FBPA
UniProtKB entry
P14223Swiss-Prot
Residues / weight
369 residues · 40,105 Da
Also known as
4.1.2.13 · 41 kDa antigen · PfAldo

Resolves to

Protein
UniProtP14223UniProt nameALF_PLAFA
Structure
PDB1A5CPDB2EPHPDB2PC4
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fructose-bisphosphate aldolase, how selective are they, and which programs against it are still in active trials?

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