V-type proton ATPase catalytic subunit A

BE0009200ProteinPlasmodium falciparum (isolate 3D7)vapA

Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
vapA
UniProtKB entry
Q76NM6Swiss-Prot
Residues / weight
611 residues · 68,576 Da
Also known as
3.6.3.14 · 7.1.2.2 · V-ATPase 69 kDa subunit · V-ATPase subunit A · Vacuolar proton pump subunit alpha

Resolves to

Protein
UniProtQ76NM6UniProt nameVATA_PLAF7
Gene
NCBI Gene814043
Pharmacology
KEGGpfa:PF13_0065
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on V-type proton ATPase catalytic subunit A, how selective are they, and which programs against it are still in active trials?

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