Plasmepsin I

BE0009204ProteinPlasmodium falciparum (isolate 3D7)PMI

During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. It is acted on by 1 drug in DrugBank.

Gene name
PMI
UniProtKB entry
Q7KQM4Swiss-Prot
Cellular location
Vacuole
Residues / weight
452 residues · 51,461 Da
Also known as
3.4.23.38 · Aspartic hemoglobinase I · PfAPG · Plasmepsin 1 · Plasmepsin-1

Resolves to

Protein
UniProtQ7KQM4UniProt namePLM1_PLAF7
Gene
NCBI Gene811658
Pharmacology
KEGGpfa:PF14_0076
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Plasmepsin I, how selective are they, and which programs against it are still in active trials?

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