Adenosylhomocysteinase

BE0009225ProteinPlasmodium falciparum (isolate 3D7)

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. It is acted on by 1 drug in DrugBank.

UniProtKB entry
P50250Swiss-Prot
Residues / weight
479 residues · 53,839 Da
Also known as
3.13.2.1 · 3.3.1.1 · AdoHcyase · PfSAHH · S-adenosyl-L-homocysteine hydrolase

Resolves to

Protein
UniProtP50250UniProt nameSAHH_PLAF7
Gene
NCBI Gene813025
Pharmacology
KEGGpfa:PFE1050w
Structure
PDB1V8B
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenosylhomocysteinase, how selective are they, and which programs against it are still in active trials?

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