Plasmepsin III

BE0009244ProteinPlasmodium falciparum (isolate 3D7)PMIII

During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) or globins (PubMed:16624575). It is acted on by 1 drug in DrugBank.

Gene name
PMIII
UniProtKB entry
Q8IM15TrEMBL
Residues / weight
451 residues · 51,693 Da
Also known as
3.4.23.39 · HAP · HAP protein · Histo-aspartic protease · PfHAP

Resolves to

Protein
UniProtQ8IM15UniProt namePLM3_PLAF7
Gene
NCBI Gene811660
Pharmacology
KEGGpfa:PF14_0078
Structure
PDB3FNSPDB3FNTPDB3FNU
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Plasmepsin III, how selective are they, and which programs against it are still in active trials?

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