2-Cys peroxiredoxin

BE0009251ProteinPlasmodium falciparum (isolate 3D7)Trx-Px1

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. It is acted on by 1 drug in DrugBank.

Gene name
Trx-Px1
UniProtKB entry
Q8IL80TrEMBL
Residues / weight
195 residues · 21,807 Da
Also known as
1.11.1.24 · 2-Cys Prx · PfTPx-1 · Pftpx1 · Thioredoxin peroxidase 1

Resolves to

Protein
UniProtQ8IL80UniProt nameTPX1_PLAF7
Gene
NCBI Gene811950
Pharmacology
KEGGpfa:PF14_0368
Drugs

What you can answer from here — as of February 03, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 2-Cys peroxiredoxin, how selective are they, and which programs against it are still in active trials?

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