Calcium-dependent protein kinase 4

BE0009256ProteinPlasmodium falciparum (isolate 3D7)CDPK4

Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141). It is acted on by 1 drug in DrugBank.

Gene name
CDPK4
UniProtKB entry
Q8IBS5Swiss-Prot
Residues / weight
528 residues · 60,779 Da
Also known as
2.7.11.1 · CDPK4 · CPK4 · PfCDPK4

Resolves to

Protein
UniProtQ8IBS5UniProt nameCDPK4_PLAF7
Gene
NCBI Gene2655116
Pharmacology
KEGGpfa:PF07_0072
Structure
PDB4QOXPDB4RGJ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcium-dependent protein kinase 4, how selective are they, and which programs against it are still in active trials?

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