Bone morphogenetic protein receptor type-2

BE0009324ProteinHumansBMPR2

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. It is acted on by 4 drugs in DrugBank.

Gene name
BMPR2
UniProtKB entry
Q13873Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,038 residues · 115,200 Da
Also known as
2.7.11.30 · BMP type II receptor · BMP type-2 receptor · BMPR-2 · BMPR-II

Resolves to

Protein
UniProtQ13873UniProt nameBMPR2_HUMAN
Gene
HGNCHGNC:1078NCBI Gene659GeneCardsBMPR2
Pharmacology
IUPHAR/GtoPdb1794KEGGhsa:659
Structure
PDB2HLQPDB3G2FPDB6UNP
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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43GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bone morphogenetic protein receptor type-2, how selective are they, and which programs against it are still in active trials?

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