Deazaflavin-dependent nitroreductase

BE0009325ProteinMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)ddn

Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. It is acted on by 2 drugs in DrugBank.

Gene name
ddn
UniProtKB entry
P9WP15Swiss-Prot
Cellular location
Cell membrane
Residues / weight
151 residues · 17,371 Da
Also known as
1.-.-.- · F420H(2)-dependent quinone reductase Ddn · Fqr

Resolves to

Protein
UniProtP9WP15UniProt nameDDN_MYCTU
Gene
NCBI Gene887496
Pharmacology
KEGGmtu:Rv3547
Structure
PDB3R5LPDB3R5PPDB3R5R
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Deazaflavin-dependent nitroreductase, how selective are they, and which programs against it are still in active trials?

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