Alpha-L-iduronidase

BE0009329ProteinHumansIDUA

Lysosomal hydrolase responsible for the degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. It is acted on by 3 drugs in DrugBank.

Gene name
IDUA
UniProtKB entry
P35475Swiss-Prot
Cellular location
Lysosome
Residues / weight
653 residues · 72,669 Da
Also known as
3.2.1.76

Resolves to

Protein
UniProtP35475UniProt nameIDUA_HUMAN
Gene
HGNCHGNC:5391NCBI Gene3425GeneCardsIDUA
Pharmacology
KEGGhsa:3425
Structure
PDB3W81PDB3W82PDB4KGJ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-L-iduronidase, how selective are they, and which programs against it are still in active trials?

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