Arylsulfatase B

BE0009330ProteinHumansARSB

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). It is acted on by 3 drugs in DrugBank.

Gene name
ARSB
UniProtKB entry
P15848Swiss-Prot
Cellular location
Lysosome
Residues / weight
533 residues · 59,687 Da
Also known as
3.1.6.12 · ASB · G4S · N-acetylgalactosamine-4-sulfatase

Resolves to

Protein
UniProtP15848UniProt nameARSB_HUMAN
Gene
HGNCHGNC:714NCBI Gene411GeneCardsARSB
Pharmacology
KEGGhsa:411
Structure
PDB1FSU
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Arylsulfatase B, how selective are they, and which programs against it are still in active trials?

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