Thyroxine 5-deiodinase

BE0009333ProteinHumansDIO3

Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722). It is acted on by 3 drugs in DrugBank.

Gene name
DIO3
UniProtKB entry
P55073Swiss-Prot
Cellular location
Cell membrane
Residues / weight
304 residues · 33,947 Da
Also known as
1.21.99.3 · 5DIII · DIOIII · ITDI3 · TXDI3

Resolves to

Protein
UniProtP55073UniProt nameIOD3_HUMAN
Gene
HGNCHGNC:2885NCBI Gene1735GeneCardsDIO3
Pharmacology
KEGGhsa:1735
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thyroxine 5-deiodinase, how selective are they, and which programs against it are still in active trials?

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