Beta,beta-carotene 15,15'-dioxygenase

BE0009340ProteinHumansBCO1

Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. It is acted on by 2 drugs in DrugBank.

Gene name
BCO1
UniProtKB entry
Q9HAY6Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
547 residues · 62,637 Da
Also known as
1.13.11.63 · BCDO · BCDO1 · BCMO1 · Beta-carotene dioxygenase 1

Resolves to

Protein
UniProtQ9HAY6UniProt nameBCDO1_HUMAN
Gene
HGNCHGNC:13815NCBI Gene53630GeneCardsBCO1
Pharmacology
KEGGhsa:53630
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta,beta-carotene 15,15'-dioxygenase, how selective are they, and which programs against it are still in active trials?

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