STE20/SPS1-related proline-alanine-rich protein kinase

BE0009391ProteinHumansSTK39

Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). It is acted on by 2 drugs in DrugBank.

Gene name
STK39
UniProtKB entry
Q9UEW8Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
545 residues · 59,473 Da
Also known as
2.7.11.1 · DCHT · PASK · Serine/threonine-protein kinase 39 · SPAK

Resolves to

Protein
UniProtQ9UEW8UniProt nameSTK39_HUMAN
Gene
HGNCHGNC:17717NCBI Gene27347GeneCardsSTK39
Pharmacology
IUPHAR/GtoPdb2224KEGGhsa:27347
Structure
PDB7O86
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on STE20/SPS1-related proline-alanine-rich protein kinase, how selective are they, and which programs against it are still in active trials?

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