Serine/threonine-protein kinase TBK1

BE0009394ProteinHumansTBK1

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). It is acted on by 1 drug in DrugBank.

Gene name
TBK1
UniProtKB entry
Q9UHD2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
729 residues · 83,642 Da
Also known as
2.7.11.1 · NAK · NF-kappa-B-activating kinase · T2K · TANK-binding kinase 1

Resolves to

Protein
UniProtQ9UHD2UniProt nameTBK1_HUMAN
Gene
HGNCHGNC:11584NCBI Gene29110GeneCardsTBK1
Pharmacology
IUPHAR/GtoPdb2237KEGGhsa:29110
Structure
PDB4EFOPDB4EUTPDB4EUU
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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25GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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56+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase TBK1, how selective are they, and which programs against it are still in active trials?

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