Tyrosine-protein kinase receptor Tie-1

BE0009396ProteinHumansTIE1

Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. It is acted on by 1 drug in DrugBank.

Gene name
TIE1
UniProtKB entry
P35590Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,138 residues · 125,089 Da
Also known as
2.7.10.1 · TIE

Resolves to

Protein
UniProtP35590UniProt nameTIE1_HUMAN
Gene
HGNCHGNC:11809NCBI Gene7075GeneCardsTIE1
Pharmacology
IUPHAR/GtoPdb1841KEGGhsa:7075
Structure
PDB5N06
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
10GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
9+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Tyrosine-protein kinase receptor Tie-1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In