Serine/threonine-protein kinase tousled-like 1

BE0009397ProteinHumansTLK1

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. It is acted on by 1 drug in DrugBank.

Gene name
TLK1
UniProtKB entry
Q9UKI8Swiss-Prot
Cellular location
Nucleus
Residues / weight
766 residues · 86,699 Da
Also known as
2.7.11.1 · KIAA0137 · PKU-beta · Tousled-like kinase 1

Resolves to

Protein
UniProtQ9UKI8UniProt nameTLK1_HUMAN
Gene
HGNCHGNC:11841NCBI Gene9874GeneCardsTLK1
Pharmacology
KEGGhsa:9874
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase tousled-like 1, how selective are they, and which programs against it are still in active trials?

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