Tyrosine-protein kinase receptor UFO

BE0009412ProteinHumansAXL

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. It is acted on by 13 drugs in DrugBank.

Gene name
AXL
UniProtKB entry
P30530Swiss-Prot
Cellular location
Cell membrane
Residues / weight
894 residues · 98,336 Da
Also known as
2.7.10.1 · AXL oncogene · UFO

Resolves to

Protein
UniProtP30530UniProt nameUFO_HUMAN
Gene
HGNCHGNC:905NCBI Gene558GeneCardsAXL
Pharmacology
IUPHAR/GtoPdb1835KEGGhsa:558
Structure
PDB2C5DPDB4RA0PDB5U6B
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
20Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
21GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
60+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Tyrosine-protein kinase receptor UFO, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In