Calcium/calmodulin-dependent protein kinase type 1

BE0009417ProteinHumansCAMK1

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. It is acted on by 1 drug in DrugBank.

Gene name
CAMK1
UniProtKB entry
Q14012Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
370 residues · 41,337 Da
Also known as
2.7.11.17 · CaM kinase I · CaM kinase I alpha · CaM-KI · CaMKI-alpha

Resolves to

Protein
UniProtQ14012UniProt nameKCC1A_HUMAN
Gene
HGNCHGNC:1459NCBI Gene8536GeneCardsCAMK1
Pharmacology
KEGGhsa:8536
Structure
PDB4FG7PDB4FG8PDB4FG9
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcium/calmodulin-dependent protein kinase type 1, how selective are they, and which programs against it are still in active trials?

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