Dual specificity protein kinase CLK2

BE0009425ProteinHumansCLK2

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. It is acted on by 3 drugs in DrugBank.

Gene name
CLK2
UniProtKB entry
P49760Swiss-Prot
Cellular location
Nucleus
Residues / weight
499 residues · 60,090 Da
Also known as
2.7.12.1 · CDC-like kinase 2

Resolves to

Protein
UniProtP49760UniProt nameCLK2_HUMAN
Gene
HGNCHGNC:2069NCBI Gene1196GeneCardsCLK2
Pharmacology
IUPHAR/GtoPdb1991KEGGhsa:1196
Structure
PDB3NR9PDB5UNPPDB6FYI
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity protein kinase CLK2, how selective are they, and which programs against it are still in active trials?

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