Dual specificity tyrosine-phosphorylation-regulated kinase 1B

BE0009432ProteinHumansDYRK1B

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. It is acted on by 2 drugs in DrugBank.

Gene name
DYRK1B
UniProtKB entry
Q9Y463Swiss-Prot
Cellular location
Nucleus
Residues / weight
629 residues · 69,197 Da
Also known as
2.7.12.1 · Minibrain-related kinase · MIRK · Mirk protein kinase

Resolves to

Protein
UniProtQ9Y463UniProt nameDYR1B_HUMAN
Gene
HGNCHGNC:3092NCBI Gene9149GeneCardsDYRK1B
Pharmacology
IUPHAR/GtoPdb2010KEGGhsa:9149
Structure
PDB8C2Z
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity tyrosine-phosphorylation-regulated kinase 1B, how selective are they, and which programs against it are still in active trials?

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