Interferon-induced, double-stranded RNA-activated protein kinase

BE0009434ProteinHumansEIF2AK2

IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929,... It is acted on by 4 drugs in DrugBank.

Gene name
EIF2AK2
UniProtKB entry
P19525Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
551 residues · 62,094 Da
Also known as
2.7.11.1 · eIF-2A protein kinase 2 · Eukaryotic translation initiation factor 2-alpha kinase 2 · Interferon-inducible RNA-dependent protein kinase · P1/eIF-2A protein kinase

Resolves to

Protein
UniProtP19525UniProt nameE2AK2_HUMAN
Gene
HGNCHGNC:9437NCBI Gene5610GeneCardsEIF2AK2
Pharmacology
IUPHAR/GtoPdb2016KEGGhsa:5610
Structure
PDB1QU6PDB2A19PDB2A1A
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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75+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interferon-induced, double-stranded RNA-activated protein kinase, how selective are they, and which programs against it are still in active trials?

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