Ephrin type-A receptor 3

BE0009437ProteinHumansEPHA3

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 1 drug in DrugBank.

Gene name
EPHA3
UniProtKB entry
P29320Swiss-Prot
Cellular location
Cell membrane
Residues / weight
983 residues · 110,130 Da
Also known as
2.7.10.1 · EK4 · EPH-like kinase 4 · Eph-like tyrosine kinase 1 · ETK

Resolves to

Protein
UniProtP29320UniProt nameEPHA3_HUMAN
Gene
HGNCHGNC:3387NCBI Gene2042GeneCardsEPHA3
Pharmacology
IUPHAR/GtoPdb1823KEGGhsa:2042
Structure
PDB2GSFPDB2QO2PDB2QO7
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-A receptor 3, how selective are they, and which programs against it are still in active trials?

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