Ephrin type-A receptor 4

BE0009438ProteinHumansEPHA4

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 1 drug in DrugBank.

Gene name
EPHA4
UniProtKB entry
P54764Swiss-Prot
Cellular location
Cell membrane
Residues / weight
986 residues · 109,859 Da
Also known as
2.7.10.1 · EK8 · EPH-like kinase 8 · HEK8 · SEK

Resolves to

Protein
UniProtP54764UniProt nameEPHA4_HUMAN
Gene
HGNCHGNC:3388NCBI Gene2043GeneCardsEPHA4
Pharmacology
IUPHAR/GtoPdb1824KEGGhsa:2043
Structure
PDB2LW8PDB2WO1PDB2WO2
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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46GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-A receptor 4, how selective are they, and which programs against it are still in active trials?

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