Ephrin type-A receptor 6

BE0009439ProteinHumansEPHA6

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 1 drug in DrugBank.

Gene name
EPHA6
UniProtKB entry
Q9UF33Swiss-Prot
Cellular location
Membrane
Residues / weight
1,036 residues · 116,378 Da
Also known as
2.7.10.1 · EHK-2 · EHK2 · EK12 · EPH homology kinase 2

Resolves to

Protein
UniProtQ9UF33UniProt nameEPHA6_HUMAN
Gene
HGNCHGNC:19296NCBI Gene285220GeneCardsEPHA6
Pharmacology
KEGGhsa:285220
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-A receptor 6, how selective are they, and which programs against it are still in active trials?

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