Ephrin type-A receptor 8

BE0009440ProteinHumansEPHA8

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 1 drug in DrugBank.

Gene name
EPHA8
UniProtKB entry
P29322Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,005 residues · 111,002 Da
Also known as
2.7.10.1 · EEK · EK3 · EPH- and ELK-related kinase · EPH-like kinase 3

Resolves to

Protein
UniProtP29322UniProt nameEPHA8_HUMAN
Gene
HGNCHGNC:3391NCBI Gene2046GeneCardsEPHA8
Pharmacology
IUPHAR/GtoPdb1828KEGGhsa:2046
Structure
PDB1UCVPDB1X5LPDB3KUL
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-A receptor 8, how selective are they, and which programs against it are still in active trials?

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