Ephrin type-B receptor 1

BE0009441ProteinHumansEPHB1

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 2 drugs in DrugBank.

Gene name
EPHB1
UniProtKB entry
P54762Swiss-Prot
Cellular location
Cell membrane
Residues / weight
984 residues · 109,884 Da
Also known as
2.7.10.1 · EK6 · ELK · EPH tyrosine kinase 2 · EPH-like kinase 6

Resolves to

Protein
UniProtP54762UniProt nameEPHB1_HUMAN
Gene
HGNCHGNC:3392NCBI Gene2047GeneCardsEPHB1
Pharmacology
IUPHAR/GtoPdb1830KEGGhsa:2047
Structure
PDB2DJSPDB2EAOPDB3ZFX
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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32GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-B receptor 1, how selective are they, and which programs against it are still in active trials?

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