Tyrosine-protein kinase Fer

BE0009443ProteinHumansFER

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. It is acted on by 3 drugs in DrugBank.

Gene name
FER
UniProtKB entry
P16591Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
822 residues · 94,637 Da
Also known as
2.7.10.2 · Feline encephalitis virus-related kinase FER · Fujinami poultry sarcoma/Feline sarcoma-related protein Fer · p94-Fer · Proto-oncogene c-Fer

Resolves to

Protein
UniProtP16591UniProt nameFER_HUMAN
Gene
HGNCHGNC:3655NCBI Gene2241GeneCardsFER
Pharmacology
IUPHAR/GtoPdb2022KEGGhsa:2241
Structure
PDB2KK6PDB6KC4
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase Fer, how selective are they, and which programs against it are still in active trials?

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