Tyrosine-protein kinase Fes/Fps

BE0009444ProteinHumansFES

Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. It is acted on by 2 drugs in DrugBank.

Gene name
FES
UniProtKB entry
P07332Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
822 residues · 93,496 Da
Also known as
2.7.10.2 · Feline sarcoma/Fujinami avian sarcoma oncogene homolog · FPS · p93c-fes · Proto-oncogene c-Fes

Resolves to

Protein
UniProtP07332UniProt nameFES_HUMAN
Gene
HGNCHGNC:3657NCBI Gene2242GeneCardsFES
Pharmacology
IUPHAR/GtoPdb2023KEGGhsa:2242
Structure
PDB1WQUPDB2DCRPDB3BKB
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase Fes/Fps, how selective are they, and which programs against it are still in active trials?

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