Inhibitor of nuclear factor kappa-B kinase subunit epsilon

BE0009450ProteinHumansIKBKE

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling (PubMed:16840782, PubMed:18583960, PubMed:19153231, PubMed:19481526, PubMed:21138416, PubMed:22532683, PubMed:23453969, PubMed:23478265, PubMed:24882218,... It is acted on by 1 drug in DrugBank.

Gene name
IKBKE
UniProtKB entry
Q14164Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
716 residues · 80,462 Da
Also known as
2.7.11.1 · 2.7.11.10 · I-kappa-B kinase epsilon · IkBKE · IKK-E

Resolves to

Protein
UniProtQ14164UniProt nameIKKE_HUMAN
Gene
HGNCHGNC:14552NCBI Gene9641GeneCardsIKBKE
Pharmacology
IUPHAR/GtoPdb2040KEGGhsa:9641
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inhibitor of nuclear factor kappa-B kinase subunit epsilon, how selective are they, and which programs against it are still in active trials?

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