Dual specificity mitogen-activated protein kinase kinase 5

BE0009460ProteinHumansMAP2K5

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. It is acted on by 1 drug in DrugBank.

Gene name
MAP2K5
UniProtKB entry
Q13163Swiss-Prot
Residues / weight
448 residues · 50,111 Da
Also known as
2.7.12.2 · MAP kinase kinase 5 · MAPK/ERK kinase 5 · MAPKK 5 · MEK 5

Resolves to

Protein
UniProtQ13163UniProt nameMP2K5_HUMAN
Gene
HGNCHGNC:6845NCBI Gene5607GeneCardsMAP2K5
Pharmacology
IUPHAR/GtoPdb2066KEGGhsa:5607
Structure
PDB2NPTPDB2O2VPDB4IC7
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity mitogen-activated protein kinase kinase 5, how selective are they, and which programs against it are still in active trials?

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